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In Escape Dead Island Infected are only seen mostly wearing Doctor Outfits from GeoPharm. Therefore, as they have not been fully consumed by the infection, they have not suffered any decay to their body which would reduce their speed and mobility. This suggests that Infected are humans undergoing the first stages of the zombification process and that, as the infection takes hold, they will eventually transform into Walkers - thus gaining the increased health (and drastically reduced speed, perhaps by means of rigor mortis).

They are distinguishable up close by their snarling demeanor and the skin worn off of their hands (most likely due to heavy clawing of doors, barricades, and survivors), exposing the muscle underneath. In this way, Infected appear largely like a living human (indeed, many NPCs find themselves ambushed and mortally wounded because they cannot easily distinguish between the Infected and a survivor in need of rescue). In fact, many of them still have intact clothing and what appear to be fresh bandages. Infected have bloodshot eyes and small red lesions on their skin, but lack the gaping wounds and advanced decay that most Walkers exhibit. This is possibly due to the Outbreak on the Island was beginning and most people turned into the early stage of a Walker. Infected are the most common type of zombie in the Ryder White's Campaign DLC. They are also the only type of zombie capable of climbing. Infected are relatively dangerous, especially when dealing with more than one at a time, and should be fought with caution, as they can quickly deplete the player's health due to the speed with which they attack. They can often be dispatched with one or two melee weapon attacks, especially when struck in the head.

Infected are significantly faster than Walkers and Thugs, but have far less health. Before Patch 1.3, their attack could interrupt the player's actions. Infected swing their arms wildly while sprinting toward the player.

Infected most often spawn immobile in the environment, but will produce a shrill scream and sprint directly toward the player when in range, quickly closing the distance and striking with surprising force and speed.